Treatments

The pandemic caused by SARS-CoV-2 is the result of zoonotic transmission, that is, from animal to man. This type of transmission risks being at the origin of more and more epidemics since human activities tend to promote close contact with animal reservoirs. The current crisis is itself a symptom of other future problems. It is […]

Severe cases of COVID-19 are linked to hyper-inflammation in association with a “cytokine storm”, bringing about lung function failure and acute respiratory syndrome. However other organs such as the liver (in 60% of severe cases), the vascular system, the brain or the kidneys can also be affected for reasons that we don’t yet fully understand. […]

Paquinimod is a specific inhibitor of S1001A8/A9 alarmins and significantly reduces numbers of the neutrophil sub-population (abnormal polynuclear neutrophils). This molecule seems to have the therapeutic potential to suppress an uncontrolled immune response associated with the pathology observed in severe forms of COVID-19. How does Paquinimod work? It must be remembered that innate immunity is […]

One of the difficulties in the fight against SARS-CoV-2 is that virus mutations may enable it to avoid the action of antibodies produced after vaccination or administered via passive therapies. Mutations of the spike (S) protein may enable the virus to avoid the effects of anti-S neutralizing antibodies that usually block infection. Specifically, the spike’s […]

The SARS-CoV-2 virus carries on its surface the spike protein, responsible for its entry into cells. This protein is made up of 2 parts: the S1 domain that binds to the ACE2 cell receptor and the S2 domain that catalyzes the fusion of viral and cellular membranes to enter the cell. The S1 domain can […]

As the SARS-CoV-2 virus continues to spread and preventative vaccines are rolled out, strategies for treating COVID-19 remain necessary. The virus replication cycle is made up of numerous stages, each one a potential area for therapeutic intervention. This includes blocking the virus penetration, interesting since the medicine does not need to enter the targeted cell. […]

Blocking the activity of the TNF (Tumor Necrosis Factor) shows promise as an approach to treating COVID-19. At the present time there are very few molecules that are effective as treatments, and the large scale deployment of vaccines giving satisfactory results may be a long way off. Their effectiveness and clinical safety has to be […]

Numerous clinical trials are currently taking place to prevent or cure pneumonias caused by SARS-CoV-2. In parallel, pre-clinical research is essential in order to better understand the details of this illness, and also to identify new therapeutic targets. In order to do this, models reproducing the cycle of infection and the complex physiopathology of COVID-19 […]

Infection caused by Sars-CoV-2 can result in a wide range of clinical symptoms, from asymptomatic individuals to severe cases that may even lead to death. In severe cases, symptoms include a high fever, a dry cough, pneumonia and inflammation of the lungs. These clinical signs are above all due to a pronounced inflammatory response caused […]

The use of antibodies to combat human illness dates from the 1980s. They are the key component of the immune response. At that time, blood taken from rabbits infected with the diptheria bacteria were used to treat patients, even though the discovery of how antibodies work came later. How exactly do they work? They can recognize […]