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Popularization of research advances on COVID-19

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What after-effects one year after hospitalisation?

The COVID-19 pandemic remains a major problem for public health. It has infected more than 200 million people and there have been more than 4,3 million deaths. Post SARS-CoV-2 infection after-effects have already been reported, and this is becoming a matter for concern in view of the large number of cases. Until recently, 2 studies […]

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Are interferons an indicator of levels of severity?

Severe cases of COVID-19 are characterised by raised levels of pro-inflammatory cytokines in the blood circulation as well as by exacerbated inflammation. Interferons (IFN) are anti-viral cytokines which have been given particular attention. They are made up of 3 families: the IFN-I (⍺ and β), the IFN-II (ɣ) and the IFN-III (𝛌 1-4).  While we […]

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Long-COVID in the United States: the next health disaster scenario?

The majority of adults in the West are now vaccinated. This is the case in, for example, more than half of the adult population in the United States. Here, several preventative health measures, such as mask wearing and social distancing, have been relaxed to enable a return to near-normal life. However, the 10 to 30% […]

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SARS-CoV-2 increases the risks of heart attack

Since the beginning of the pandemic, more than 190 million people have been infected by SARS-CoV-2. The main risk for infected people is pneumonia, which can develop into acute respiratory distress with a high level of mortality. However, COVID-19 is a complex disease that can affect a number of different organs. It has been reported […]

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Rare severe cases in children

With the exception of babies, severe cases of COVID-19 occur mainly in adults. While they are liable to infection by SARS-CoV-2, children represent only 1,5% of hospitalisations. Unlike what we previously thought, they have a relatively limited role in the spread of SARS-CoV-2. They develop a complete and effective immune response after infection, as do […]

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The neurological symptoms of COVID-19

Although SARS-CoV-2 principally targets the respiratory system, COVID-19 patients may also suffer from neurological and psychiatric symptoms. These symptoms may range from loss of smell or headaches to encephalitis or stroke. These neuropathologies may be the direct consequence of brain cells being attacked by the virus, or an indirect consequence of the peripheral immune response. […]

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Autoantibodies could worsen the illness

The clinical signs of COVID-19 vary, but are characterised overall by an inappropriate immune response. We now know that the overactivation of the innate immune response contributes in large part to the physiopathology of the illness. We also know that neutralising antibodies protect us against infection by SARS-CoV-2. But recent studies suggest that any deregulation […]

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Markers of the illness’ severity

Around 20% of COVID-19 patients suffer from respiratory failure necessitating the use of oxygen or of ventilators. In general, these patients are categorised as severely or critically ill (the latter when there is a risk of death) according to a number of clinical characteristics, such as oxygen saturation. However, it is necessary to develop approaches […]

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A post-mortem cellular analysis of the lungs

Infection by SARS-CoV-2 leads in 15% of cases to severe illness associated with respiratory distress syndrome and increased morbidity and mortality. The difficulties of taking samples from patients, often limited to broncho-alveolar fluids, hinders understanding of the consequences of infection at lung tissue level. Researchers at the University of Columbia instigated a programme of rapid […]

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A multi-organ post-mortem cellular analysis

The clinical indications of COVID-19 can range from asymptomatic infection to death, the latter often caused by acute respiratory distress syndrome, hyper-inflammation or multiple organ failure. However, numerous questions remain on the physiopathology of this illness, particularly since genetic studies are compromised by the deterioration of post-mortem material. American researchers at Harvard University and the […]

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